Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors.
نویسندگان
چکیده
منابع مشابه
Estrogen enhances growth hormone receptor expression and growth hormone action in rat osteosarcoma cells and human osteoblast-like cells.
Postmenopausal bone loss is primarily due to estrogen deficiency. Recent clinical observation demonstrate that GH increases bone mass in GH deficient patients. The present study investigates whether estrogen regulates GH action and GH receptor expression in osteoblasts. 17 beta-estradiol or GH added to the culture medium as single substances did not influence rat osteosarcoma cell proliferation...
متن کاملتأثیر پلی مورفیسم های ژن های هورمون رشد growth hormone و گیرنده ژن هورمون رشد growth hormone receptor روی برخی صفات اقتصادی بز مرغز ایران
در این پژوهش به بررسی وجود پلی مورفیسم در ناحیه پروموتور و اگزون 10 ژن های gh و ghr و ارتباط آنها با صفات رشد در بزهای مرغز پرداخته شد. بدین منظور از سیاهرگ وداج تعداد 160 بز مرغز موجود در ایستگاه اصلاح نژاد استان کردستان خونگیری و dna نمونه ها با استفاده از کیت استخراج گردید. قطعه 391 جفت بازی از ژن gh و 361 جفت بازی از ژن ghr تکثیر شدند. از تفاوت چندشکلی فضایی تک رشته ها (sscp) و توالی یابی ب...
Growth hormone-releasing factor regulates growth hormone mRNA in primary cultures of rat pituitary cells.
A peptide with high intrinsic activity for specifically stimulating the secretion of immunoreactive growth hormone (GH; somatotropin) has been characterized and reproduced by total synthesis. This peptide, human pancreatic growth hormone-releasing factor, 44-amino-acid form (hpGRF1-44-NH2), was isolated from a tumor localized in the pancreas of a patient with acromegaly. We report here the effe...
متن کاملSleep in mice with nonfunctional growth hormone-releasing hormone receptors.
The role of the somatotropic axis in sleep regulation was studied by using the lit/lit mouse with nonfunctional growth hormone (GH)-releasing hormone (GHRH) receptors (GHRH-Rs) and control heterozygous C57BL/6J mice, which have a normal phenotype. During the light period, the lit/lit mice displayed significantly less spontaneous rapid eye movement sleep (REMS) and non-REMS (NREMS) than the cont...
متن کاملMedaka receptors for somatolactin and growth hormone: phylogenetic paradox among fish growth hormone receptors.
Somatolactin (SL) in fish belongs to the growth hormone/prolactin family. Its ortholog in tetrapods has not been identified and its function(s) remains largely unknown. The SL-deficient mutant of medaka (color interfere, ci) and an SL receptor (SLR) recently identified in salmon provide a fascinating field for investigating SL's function(s) in vivo. Here we isolated a medaka ortholog of the sal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)47392-4